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| LTRC Publications |
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| Malhorta D, Thimmulappa R, Navas-Acien A, Sanford A, Elliot M, Singh A, Chen L, Zhuang X, Hogg J, Pare P, Tuder RM, Biswal S. Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1. Am J Respir Crit Care Med. 2008 Sep 15;178(6):592-604. Epub 2008 Jun 12. 08-99-0028 |
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| Pilling D, Fan T, Huang D, Kaul B, Gomer RH (2009) Identification of Markers that Distinguish Monocyte-Derived Fibrocytes from Monocytes, Macrophages, and Fibroblasts. PLoS ONE 4(10): e7475. doi:10.1371/journal.pone.0007475 08-99-0026 |
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| NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury Louise Hecker, Ragini Vittal, Tamara Jones, Rajesh Jagirdar, Tracy R Luckhardt, Jeffrey C Horowitz, Subramaniam Pennathur, Fernando J Martinez, Victor J Thannickal Nature Medicine 15, 1077-1081 (23 August 2009) doi:10.1038/nm.2005 Letter 05-03-0002 |
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| Malhotra, D#, Thimullappa, RK#, Vij, N*, Navas-Acien, A, Sussan T, Merali, S, Zhang, Li-C, Kelsen, SG, Myers A, Tuder, R and Biswal S. Heightened endoplasmic reticulum stress in COPD lungs: the role of Nrf2 regulated proteasomal activity. Am J Resp Critical Care Med (Accepted, in press). * 2nd author, # co-author equal contribution 08-99-0028 |
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| Han MK, Swigris J, Liu L, Barthomai B, Murray S, Giardino N, Thompson B, Frederick M, Li D, Schwarz M, Limper A, Flaherty K, Martinez FJ. Gender influences health-related Quality of Life in IPF. Respir Med. 2009 Dec 23 (Epub ahead of print). 08-03-0002 |
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| Yih-Sheng Yang, Meng-Chun W. Yang, Yuhong Guo, Olantunji W. Williams and Jonathan C. Weissler. PLAGL2 expression-induced lung epithelium damages at bronchiolar alveolar duct junction in emphysema: bNip3- and SP-C-associated cell death/injury activity. Am J Physiol Lung Cell Mol Physiol 297: L455-L466, 2009 Jul 2; 08-99-0034 |
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| Yamashiro, T., Matsuoka, S., J. Bartholmai, B., San José Estépar, R., Ross, J.C., Diaz, A., Murayama, S., Silverman, E.K., Hatabu, H., Washko, G.R. (2010). Collapsibility of Lung Volume by Paired Inspiratory and Expiratory CT Scans:. Correlations with Lung Function and Mean Lung Density. Academic Radiology, . Article in Press. 08-99-0014 |
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| Daniel J. Schneider, Janci C. Lindsay, Yang Zhou, Jose G. Molina, and Michael R. Blackburn. “Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease”. The FASEB Journal, fj.09-140772; August 31, 2009. 08-99-0020 |
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| Yang Zhou, Jayasimha N. Murthy, Dewan Zeng, Luiz Belardinelli, Michael R. Blackburn. Alterations in Adenosine Metabolism and Signaling in Patients with Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis. PLoS ONE: Research Article, published 16 Feb 2010 | doi:10.1371/journal.pone.0009224 08-99-0020 |
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| Han, M.K., Bartholmai, B., Liu, L.X., Murray, S., Curtis, J.L., Sciurba, F.C., Kazerooni, E.A., Thompson, B., Frederick, M., Li, D., Schwarz, M., Limper, A., Freeman, C., Landreneau, R.J., Wise, R., Martinez, F.J. (2009). Clinical significance of radiologic characterizations in COPD. COPD: Journal of Chronic Obstructive Pulmonary Disease, 6 (6), pp. 459-467. 07-05-0001 |
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| Robert Vassallo, Paula R Walters, Jeffrey Lamont, Theodore J Kottom, Eunhee S Yi, Andrew H Limper. Cigarette smoke promotes dendritic cell accumulation in COPD; a Lung Tissue Research Consortium study. Respiratory Research 2010, 11:45 (26 April 2010). 09-01-0002 |
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| Freeman CM, Martinez FJ, Han M-LK, Ames TM, Chensue SW, Todt JC, Arenberg DA, Meldrum CA, Getty C, McCloskey L, Curtis JL. Lung dendritic cell expression of maturation molecules increases with worsening COPD. Am J Respir Crit Care Med 2009; 180: 1179-1188. PMID: 19729666. 05-03-0001 |
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| Freeman CM, Han M-LK, Martinez FJ, Murray S, Liu LX, Chensue SW, Polak T, Sonstein J, Todt JC, Ames TM, Arenberg DA, Meldrum CA, Getty C, McCloskey L, Curtis JL. Cytotoxic potential of lung CD8+ T cells in COPD is increased with disease severity and by in vitro stimulation with IL-18 and IL-15. J Immunol 2010; 184:6504-13. PMID: 20427767. 05-03-0001 |
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| Manish Bodas, Taehong Min, Steven Mazur and Neeraj Vij. Critical Modifier Role of Membrane-Cystic Fibrosis Transmembrane Conductance Regulator-Dependent Ceramide Signaling in Lung Injury and Emphysema. J Immunol 2011; 186;602-613. 07-99-0002 |
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| Taehong Min, Manish Bodas, Steven Mazur and Neeraj Vij. Critical Role of Proteostasis-imbalance in Pathogenesis of COPD and Severe Emphysema. J Mol Med 2011; DOI10.1007/s00109-011-0732-8. 09-99-0027 |
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| Cho JH, Gelinas R, Wang K, Etheridge A, Piper MG, Batte K, Dakhallah D, Price J,Bornman D, Zhang S, Marsh C, Galas D. Systems biology of interstitial lung diseases: integration of mRNAand miRNA expression changes. BMC Med Genomics. 2011 Jan 17; 4(1):8). 07-99-0006 |
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| Han MK, Ismailoglu U, Coelho A, Bartholmai B, Toews GB, Schmidt S, Flaherty KR, Martinez FJ, HogaboamCM. Significance of hCCL22 as a biomarker in IPF. Am J Respir Crit Care Med 2010;181:A1102. 08-03-0002 |
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| Laura L. Koth, C.J. Cambier, Almut Ellwanger, Margaret Solon, Lydia Hou, Lewis L. Lanier, Clare L. Abram, Jessica A. Hamerman and Prescott G. Woodruff. DAP12 Is Required for Macrophage Recruitment to the Lung in Response to Cigarette Smoke and Chemotaxis toward CCL2. J. Immunol 2010;184;6522-6528. 08-99-0040 |
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| Michael E Ezzie, Melissa Crawford, Ji-Hoon Cho, Robert Orellana, Shile Zhang, Richard Gelinas, Kara Batte, Lianbo Yu, Gerard Nuovo, David Galas, Philip Diaz, Kai Wang, S Patrick Nana-Sinkam. Gene expression networks in COPD: microRNA and mRNA regulation;http://thorax.bmj.com/content/early/2011/09/22/thoraxjnl-2011-200089.full.pdf.Concept Sheet Number: 07-99-0008 |
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| Steven G. Kelsen, Mark O. Aksoy, Mary Georgy, Richard Hershman, Rong Ji, Xiu Xia Li, Matthew Hurford, Charalambos Solomides, Wissam Chatila, and Victor Kim. Lymphoid Follicle Cells in Chronic Obstructive Pulmonary Disease Over express the Chemokine Receptor CXCR3; Am J Respir Crit Care Med Vol 179. pp 799–805, 2009. Concept Sheet Number: 08-99-0007 |
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| Xiaobo Zhou, Rebecca M. Baron, Megan Hardin, Michael H. Cho, Jan Zielinski, Iwona Hawrylkiewicz, Pawel Sliwinski, Crain P. Hersh, John D. Mancini, Ke Lu, Derek Thibault, Amy L. Donahue, Barbara J. Klanderman, Bernard Rosner, Benjamin A. Raby, Quan Lu, Adriana M. Geldart, Mathew D. Layne, Mark A. Perrella, Scott T. Weiss, Augustine M. K. Choi and Edwin K. Silverman. Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP; Human Molecular Genetics, 2011, 1–11, doi:10.1093/hmg/ddr569. Concept Sheet Number: 10-99-0004 |
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| Schaeffer M.W., Sinha Roy, S., Mukherjee, S., Ong D., Das, S.K. Uptake of all-trans retinoic acid-containing aerosol by inhalation to lungs in a guinea pig model system – a pilot study, Expt. Lung Res 36: 593-601, 2010, DOI: 10.3109/01902141003790155, PMCID: PMC3058486, NIHMSID:NIHMS223930. Concept Sheet Number: 09-99-0016 |
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| Schaeffer MW, Sinha Roy S, Mukherjee S, Nohr D, Wolter M, Biesalski HK, Ong DE, Das SK . Qualitative and quantitative analysis of retinol, retinyl esters, tocopherols and selected carotenoids out of various internal organs from different species by HPLC. Anal. Methods, 2: 1320-1332, 2010, DOI: 10.1039/c0ay00288g, 2010, PMCID: PMC2957904, NIHMSID: NIHMS223934 Concept Sheet Number: 09-99-0016 |
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| Schaeffer MW, Sinha Roy S, Mukherjee S, Das SK. Vitamin A, Vitamin E, Lutein and Beta-carotene in Lung Tissues from Subjects with Chronic Obstructive Pulmonary Disease and Emphysema, In Press, On Line journal of Respiratory Diseases. Concept Sheet Number: 11-99-0004 |
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| Napolitano JR, Liu MJ, Bao S, Crawford M, Nana-Sinkam P, Cormet-Boyaka E, Knoell DL. Cadmium-mediated toxicity of lung epithelia is enhanced through NF-?B-mediated transcriptional activation of the human zinc transporter ZIP8. Am J Physiol Lung Cell Mol Physiol. 2012 Feb 17. [Epub ahead of print] Concept Sheet Number: 07-99-0008 |
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| Reddy NM, Vegiraju S, Irving A, Paun BC, Luzina IG, Atamas SP, Biswal S, Navas-Acien A, Mitzner W and Reddy SP (2012). Targeted deletion of Jun/AP-1 in alveolar epithelial cells causes progressive emphysema and worsens cigarette smoke-induced lung inflammation. American Journal of Pathology 180:562-74. PMID: 22265050 Concept Sheet Number: 09-99-0010 |
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| Stallings-Mann, M.L., Waldmann, J., Zhang, Y., Miller, E., Gauthier, M.L., Visscher, D.W., Downey, G.P.,Radisky, E.S., Fields, A.P., Radisky, D.C. Matrix metalloproteinase induction of Rac1b, a key effector of lungcancer progression. Sci. Trans. Med. 2012, in press. CS 11-99-0003 |
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| Berry CE, Drummond MB, Han MK, Li D, Fuller C, Limper AH, Martinez FJ, Schwarz MI, Sciurba FC, Wise RA. Relationship between lung function impairment and health-related quality of life in COPD and ILD. Chest. 2012 May 10. epub. CS 09-99-0008 |
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| Chand HS, Harris JF, Mebratu Y, Chen Y, Wright PS, Randell SH, Tesfaigzi Y. Intracellular insulin-like growth factor-1 induces Bcl-2 expression in airway epithelial cells. J Immunol. 2012 May 1;188(9):4581-9. Epub 2012 Mar 28. CS 08-99-0018 |
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| Zhou X, Baron RM, Hardin M, Cho MH, Zielinski J, Hawrylkiewicz I, Sliwinski P, Hersh CP, Mancini JD, Lu K, Thibault D, Donahue AL, Klanderman BJ, Rosner B, Raby BA, Lu Q, Geldart AM, Layne MD, Perrella MA, Weiss ST, Choi AM, Silverman EK. Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. Hum Mol Genet. 2012 Mar 15;21(6):1325-35. Epub 2011 Dec 2. CS 09-99-0015 |
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| Podowski M, Calvi C, Metzger S, Misono K, Poonyagariyagorn H, Lopez-Mercado A, Ku T, Lauer T, McGrath-Morrow S, Berger A, Cheadle C, Tuder R, Dietz HC, Mitzner W, Wise R, Neptune E. Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in mice. J Clin Invest. 2012 Jan 3;122(1):229-40. doi: 10.1172/JCI46215. Epub 2011 Dec 19 . CS 09-99-0011 |
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| Zhou Q, Pardo A, Königshoff M, Eickelberg O, Budinger GR, Thavarajah K, Gottardi CJ, Jones J, Varga J, Selman M, Sznajder JI, Raj JU, Zhou G. FASEB J. Role of von Hippel-Lindau protein in fibroblast proliferation and fibrosis. 2011 Sep;25(9):3032-44. Epub 2011 Jun 3. PMID: 21642472 CS 08-99-0031 |
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| Yilmaz C, Dane DM, Patel NC, Hsia CC. Quantifying Heterogeneity in Emphysema from High-Resolution Computed Tomography: A Lung Tissue Research Consortium Study. Acad Radiol. 2012 Oct 30. doi:10.1016/j.acra.2012.09.013. [Epub ahead of print] CS 09-99-0023 |
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| Reilkoff RA, Peng H, Murray LA, Peng X, Russell T, Montgomery R, Feghali-Bostwick C, Shaw A, Homer RJ, Gulati M, Mathur A, Elias JA, Herzog EL. Semaphorin 7a+ Regulatory T cells are Associated with Progressive IPF and are Implicated in TGF-ß1-induced Pulmonary Fibrosis. Am J Respir Crit Care Med. 2012 Dec 6. [Epub ahead of print] CS 08-99-0024 |
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| Baran CP, Fischer SN, Nuovo GJ, Kabbout MN, Hitchcock CL, Bringardner BD, McMaken S, Newland CA, Cantemir-Stone CZ, Phillips GS, Ostrowski MC, Marsh CB. Transcription factor ets-2 plays an important role in the pathogenesis of pulmonary fibrosis. Am J Respir Cell Mol Biol. 2011 Nov;45(5):999-1006. doi: 10.1165/rcmb.2010-0490OC. Epub 2011 May 11. CS 08-99-0039 |
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| My-Trang T. Dang, Chenyang Gu, Jeannie I. Klavanian, Katherine A. Jernigan, Karen H. Friderici, Yuehua Cui, Maria Molina-Molina, Julio Ancochea, Antoni Xaubet, and Bruce D. Uhal. Angiotensinogen Promoter Polymorphisms Predict Low Diffusing Capacity In U.S. and Spanish IPF Cohorts. Lung 2013. CS 07-99-0010 |
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| Beiyun Zhou,Yixin Liu, Michael Kahn, David K. Ann, Arum Han, Hongjun Wang, Cu Nguyen, PerFlodby, Qian Zhong, Manda S. Krishnaveni, Janice M. Liebler, ParvizMinoo, Edward D. Crandall, and Zea Borok. Interactions Betweenß-Catenin and Transforming Growth Factor-ß Signaling Pathways Mediate Epithelial-Mesenchymal Transitionand Are Dependent on the Transcriptional Co-activator cAMP-response Element-binding Protein (CREB)-binding Protein (CBP). THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL.287,NO.10, pp.7026–7038, March 2, 2012 CS 09-99-0002 |
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| Wu Q, Jiang D, Chu HW. Cigarette smoke induces growth differentiation factor 15 production in humanlung epithelial cells: implication in mucin overexpression. Innate Immunity 2012;18:617-626. PMID:22180562 CS 09-02-0003 |
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| Gally F, Chu HW, Bowler RP. Cigarette smoke decreases Airway epithelial FABP5 expression andpromotes Pseudomonas aeruginosa infection. PLoS One 2013;8(1):e51784.PMID: 23349676 CS 09-02-0003 |
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| Marilee J. Wick, Zoe L. Loomis, Louis B. Hersh and Edward C. Dempsey. Mechanisms that decrease human Neprilysin gene expression in cigarette smoke-induced pulmonary vascular disease. The FASEB Journal. 2012;26:873.12 CS 07-02-0003 |
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| Yue X, Lu J, Auduong L, Sides MD, Lasky JA. Overexpression of Sulf2 in idiopathic pulmonary fibrosis. Glycobiology 2013;23:709-19. CS 07-99-0005 |
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